I LOVE that town!
I highly recommend the Venetian or the Wynn... you should be able to get decent prices and they are great casinos.
Make sure to take the wife to a show or two... you can find pretty much anything you might like and the productions are fantastic. Try a magic show like Penn and Teller... very different from your traditional broadway show.
I don't gamble a lot but I love to wander around and check out the sights and sounds. You can spend days just wandering the casinos and checking out the awesome scenery.
There is a range in Vegas where you can shoot full auto weapons... great fun.
And if you are a food aficionado, this is THE town. Emeril, Battali, Flay... take your pick... the food is amazing.
Don't bother renting a car, there is a monorail that runs up and down the strip and most of the hotels have shuttles.
Great golf and the scenery is very fun... I highly recommend a trip to Hoover Dam, well worth the drive.
Finally, I recommend wearing a sport coat in Vegas... dress up a little and you will receive a much better level of service.
Look into a couple of guides to Vegas... you can have a great time and spend very little money if you know what you are doing. Have a blast!