I hunt in terrains that vary from hills to flat land, and from wide open hay fields to open woods to dense thickets. I have an array of rifles, but I have the one that is my first choice for deer hunting, and it has served well in all the various places I hunt. I've never understood why people think you need a large diameter, slow bullet to hunt in a wooded area. I've seen no evidence that those calibers fare any better than smaller, faster ones.
Just to be clear, I believe the 280 Remington, 30-06, 270, and the like are borderline overkill for Tennessee whitetail deer. I have had very good success with 243s, 30-30s, 7x57,and 257 Roberts as well. My favorite rifle just happened to be chambered in 280. I'd like it just as well, as long as it balanced the same and shot as well, if it were in any number of similar calibers.