for hunting you normally use a soft-point instead of FMJ or JHP(jacketed hollow point), for the mushrooming effect, the JHP does too much damage and destroys too much of the animal.
I dont know if you are saying that you think that a .45 will still go all the way through with a JHP or if it wont make it past the outer layer, but remember the .45ACP is the slowest, widely used semi-auto pistol cartridge(except .380ACP), only travelling at 850fps(normal pressure) normally, where as a 9mm or .40 is moving a good bit faster, and .357sig and 10mm are even faster.
IMHO, a .45ACP JHP +P is the best self-defense cartridge in a pistol available, approx. 950-1050 fps .45 caliber, 230gr. JHP projectile, will make a man think twice.
Most times a .45 wont go through an assailant, most JHPs period wont.
I dont know where to even start looking on here, but someone posted up a link to a survelliance video in a police precinct, where a suspect wasnt padded down and while he was waiting to be interrogated, pulled out a 1911 in .45 and shot himself in the head, point blank. The bullet didnt exit the other side, and I doubt a guy like that had JHP loaded in it.